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In this article we display that DNL343 lowers ISR activation and neurodegeneration brought on acutely by an optic nerve crush (ONC) damage or chronically by a germline eIF2B LOF mutation in mice. We also show that DNL343 therapy, initiated in a late phase of disorder which far more correctly replicates a clinical dosing paradigm, reversed these ISR

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Very low and fluctuating rubber price difficulties are decreasing farmers' incomes these days. Furthermore, Indonesia can be suffering from a nationwide meat deficit that's projected to take place by 2026. The integration of rubber crops and cattle can be an answer to that. This paper aims to review the model of rubber integration in several routin

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